Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Natural History With Its Numerous Co-morbidities?

Part of paid clinical trials in Richmond, Virginia.

Sponsor
Virginia Commonwealth University
Study ID
NCT05618054
Status
Recruiting
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Conditions

  • Postural Tachycardia Syndrome

Eligibility Criteria

Sex
FEMALE
Age
12 Years - 21 Years
Healthy Volunteers
Accepted

Interventions

  • Looming task — BEHAVIORAL
    Participants will be asked to look at some pictures during an fMRI scan. Participants will press a button as soon as they see the image appear.

Study Details

This study is being conducted to see how people with Postural tachycardia syndrome (POTS) make sense of the things they see. The information may help doctors to learn more about how the different parts of people's brains communicate.

Key Dates

Start date
Mar 6, 2023
Status verified
Apr 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
36 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Other: Adolescents with POTS
  • Other: Adolescents without POTS

Primary Outcome Measure

Periaqueductal gray region activation - looming task [ Time Frame: 90 minutes ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Virginia Commonwealth UniversityRichmondVirginia23298-

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By research site
Virginia Commonwealth University· Richmond, VA

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