Comparison of Body Weight Change Through Different Smeglutide Administration Methods

Sponsor
Huashan Hospital
Study ID
NCT05616052
Phase
PHASE4
Status
Unknown

Conditions

  • Weight Change, Body

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Semaglutide — DRUG
    treatment with different dosage regimes

Study Details

Investigators determined to detect the effect of smeglutide on body weight and metabolic indexes among overweight and obese participants through two different dosing programs.

Key Dates

Start date
Dec 1, 2022
Status verified
Nov 2022
Primary completion
Dec 1, 2023
Completion
Dec 1, 2023

Study Design

Enrollment
80 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: standard arm
    standard arm will start from 0.25mg per week for four weeks, then increase to 0.5mg per week for four weeks, and 1mg per week maintenance dose for 8 weeks..
  • Active Comparator: titration arm
    Titration arm dosage regime depends on the tolerance of the semaglutide from patients. The dosage will stabilize on the dose which patients could tolerate

Primary Outcome Measure

weight change in kilograms [ Time Frame: 16 weeks ]

Central Contacts

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