Neural Mechanisms of Meditation for Opioid-Treated Chronic Low Back Pain

Part of paid clinical trials in La Jolla, California.

Sponsor
University of Utah
Study ID
NCT05607381
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Meditation — BEHAVIORAL
    Participants will complete 8 sessions of meditation training with therapy as a means of coping with chronic pain and opioid-related issues.
  • Usual care — OTHER
    Participants will receive usual care for chronic low back pain (e.g., analgesic medication, pain management consultant from a physician, physical therapy, etc.).

Study Details

The purpose of this research study is to see how a mindfulness meditation-based intervention affects pain. Specifically, we are interested in understanding the pain-relieving brain mechanisms of mindfulness meditation-based therapy for patients with opioid-treated chronic low back pain.

Key Dates

Start date
Nov 30, 2022
Status verified
Jan 2026
Primary completion
Apr 30, 2027
Completion
Jun 30, 2027

Study Design

Enrollment
150 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Mindfulness
    A well-validated mindfulness meditation-based therapy \[8 sessions\] is used to teach patients to independently practice meditation to cope with pain.
  • Experimental: Meditation
    A validated meditation-based therapy \[8 sessions\] is used to teach patients to independently practice meditation to cope with pain.
  • Active Comparator: Usual Care
    Patients will receive usual medical care for chronic low back pain.

Primary Outcome Measure

Blood oxygenation level dependent (BOLD) signaling [ Time Frame: At baseline and at post-treatment (8 weeks) ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
University of California, San DiegoLa JollaCalifornia92093
Rachel Brewers
[email protected]
619-363-6407
Eric Garland, PhD (PRINCIPAL_INVESTIGATOR)
Fadel Zeidan, PhD (PRINCIPAL_INVESTIGATOR)
Center on Mindfulness and Integrative Health Intervention DevelopmentSalt Lake CityUtah84108-

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