Allergy and Immunology Natural History Study

Part of paid clinical trials in New York, New York.

Sponsor
Columbia University
Study ID
NCT05584488
Status
Recruiting
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Conditions

  • Allergic Inflammation
  • Immune Deficiency
  • Immune Dysregulation Disorder

Eligibility Criteria

Sex
ALL
Age
N/A - 99 Years
Healthy Volunteers
Accepted

Study Details

This protocol is a natural history study designed to evaluate subjects (and some family members) with suspected or identified genetic diseases of allergic inflammation or Immune Dysregulation. Patients determined by clinical history and outside evaluations to be of interest will be consented and enrolled into this study. Blood specimens, stored blood products and derivatives, saliva, hair, fingernail clippings, cord blood, umbilical cord, bone marrow, tissue biopsies and/or buccal swabs from such patients and/or their family members will be obtained for research studies related to understanding genetic and immunopathogenic bases of these diseases. Outside medical records may be obtained, and patient evaluations may be performed to correlate to research laboratory testing results.

Key Dates

Start date
Jul 16, 2010
Status verified
Feb 2026
Primary completion
Jan 31, 2027
Completion
Jan 31, 2027

Study Design

Enrollment
10,000 participants (estimated)

Arms

  • Arm: Inherited diseases of allergic inflammation or immune dysregulation
    Patients and blood relatives with disorders of allergic inflammation and immune dysregulation.

Primary Outcome Measure

Total number of underlying susceptibility trait(s) identified [ Time Frame: Up to 1 year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Columbia University Irving Medical Center / NewYork-Presbyterian HospitalNew YorkNew York10032
Yannett Franklin
[email protected]
212-305-0473
Alexis Boneparth, MD (SUB_INVESTIGATOR)
Manar Abdalgani, MBBS (SUB_INVESTIGATOR)
Emily Mace, PhD (SUB_INVESTIGATOR)
Joyce Yu, MD (SUB_INVESTIGATOR)
Joshua Milner, MD (PRINCIPAL_INVESTIGATOR)

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By research site
Columbia University Irving Medical Center / NewYork-Presbyterian Hospital· New York, NY

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