Safest Choice of Antihypertensive Regimen for Postpartum Hypertension

Conditions

• High Blood Pressure
• Maternal Hypertension
• Postpartum Complication

Eligibility Criteria

Sex

FEMALE

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Oral Nifedipine — DRUG
  Administration of oral nifedipine to control postpartum hypertension.
• Oral Labetalol — DRUG
  Administration of oral labetalol to control postpartum hypertension.

Study Details

The purpose of this investigator-initiated randomized control trial is to determine whether oral Nifedipine versus oral Labetalol is superior in controlling high blood pressures in the postpartum period.

Key Dates

Start date

May 8, 2023

Status verified

Feb 2026

Primary completion

Dec 31, 2027

Completion

Dec 31, 2027

Study Design

Enrollment

500 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Active Comparator: Oral Nifedipine
  Participants will receive oral nifedipine for blood pressure control. Dosage may initially start at one 10mg capsule by mouth three times per 24 hours (total of 30mg a day), however dosage may be increased by 30mg increments (i.e. 20mg capsule three times a day for a total of 60mg a day). Maximum dosage for oral Nifedipine will be 120mg per day.
• Active Comparator: Oral Labetalol
  Participants will receive oral labetalol for blood pressure control. Dosage may initially start at one 200mg tablet by mouth two times per 12 hours (total of 400mg every a day), however dosage may be increased by 100-200mg increments at a time. Maximum dosage for oral labetalol will be 2400mg per day.

Primary Outcome Measure

Composite maternal morbidity [ Time Frame: 0-6 weeks following delivery ]

Central Contacts

• Ashra Denise B Tugung, BSc
  9096515580
  [email protected]
• Nikia Gray-Hutto, RN, CCRP
  9095584000
  [email protected]

Locations (1)

Find similar trials in Loma Linda, CA

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