Mechanisms of Behavioral Activation (BA)

Part of paid clinical trials in Atlanta, Georgia.

Sponsor
Emory University
Study ID
NCT05548244
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
15 Years - 17 Years
Healthy Volunteers
Accepted

Interventions

  • Behavioral Activation Therapy — BEHAVIORAL
    Participants will be seen for a maximum of 16 sessions of therapy focused on increasing rewarding behaviors (16 individual therapy sessions of 1-hour, 2 of which include the BSIS component) over 16 weeks. BA intervention includes monthly booster sessions offered throughout 6-month follow up. If needed, two extra sessions will be allowed during treatment.
  • Baseline assessment procedures — BEHAVIORAL
    Completion of the K-SADS and CDRS-R to assess MDD, and the Wechsler Abbreviated Scale of Intelligence - 2nd Edition to assess IQ.

Study Details

The investigators will be comparing brain (neural) activation of depressed adolescent patients before, during and after a course of Behavioral Activation (BA) therapy using functional magnetic resonance imaging (fMRI). In particular, the project seeks to determine whether BA targets different neural mechanisms for behavioral avoidance associated with low motivation as compared to threat avoidance. A group of healthy controls will also be scanned as a comparator group for behavioral and imaging measures.

Key Dates

Start date
Jan 30, 2023
Status verified
May 2026
Primary completion
May 31, 2027
Completion
May 31, 2027

Study Design

Enrollment
136 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER

Arms

  • Experimental: MDD patients
    Participants will be seen for a maximum of 16 sessions over 16 weeks. Two extra sessions will be allowed during treatment.

Primary Outcome Measure

Change in Diagnostic Interview Status (CDRS-R) total score from baseline [ Time Frame: Baseline, week 16 post intervention ]

Central Contacts

Locations (3)

FacilityCityStateZIPSite coordinators
Child and Adolescent Mood Program (CAMP)AtlantaGeorgia30329
Wade E Craighead, PhD
[email protected]
Emory UniversityAtlantaGeorgia30322
Wade E Craighead, PhD
[email protected]
Facility for Education and Research in Neuroscience (FERN)AtlantaGeorgia30322
Michael Treadway, PhD
[email protected]

Find similar trials in Atlanta, GA

By condition
Depression
By specialty
PsychiatryMental healthBehavioral health
By research site
Child and Adolescent Mood Program (CAMP)· Atlanta, GAEmory University· Atlanta, GAFacility for Education and Research in Neuroscience (FERN)· Atlanta, GA

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