Rare and Atypical Diabetes Network
Part of paid clinical trials in Aurora, Colorado.
- Sponsor
- University of South Florida
- Study ID
- NCT05544266
- Status
- Recruiting
Conditions
- Diabetes Mellitus
- Diabetes Mellitus Progression
- Endocrine System Diseases
- Endocrine; Complications
- Glucose Intolerance
- Glucose Metabolism Disorders
- Metabolic Disease
Eligibility Criteria
- Sex
- ALL
- Age
- N/A - N/A
- Healthy Volunteers
- Not accepted
Study Details
RADIANT is a network of 14 clinical sites and several laboratories dedicated to the study of atypical diabetes. The objective of this study is to define new forms of diabetes and the unique mechanisms underlying these forms of atypical diabetes. The specific aims are to: 1. Identify and enroll individuals and families with undiagnosed rare and atypical forms of diabetes. 2. Determine the etiologic basis of the metabolic disorder among individuals and families with novel forms of rare and atypical diabetes. 3. Understand the pathophysiology of individuals and families with novel forms of rare and atypical forms of diabetes.
Key Dates
- Start date
- Sep 30, 2020
- Status verified
- Aug 2025
- Primary completion
- Sep 30, 2030
- Completion
- Sep 30, 2030
Study Design
- Enrollment
- 2,000 participants (estimated)
Primary Outcome Measure
Phenotypic and genotypic characterization of previously unknown forms of diabetes using Whole Genome Sequencing (WGS), and deeper phenotyping methods [ Time Frame: Through study completion, an average of 3 years. ]
Central Contacts
- Jeffrey Krischer, PhD813-396-9501
Locations (13)
| Facility | City | State | ZIP | Site coordinators |
|---|---|---|---|---|
| University of Colorado- Denver | Aurora | Colorado | 80045 | Neda Rasouli, MD (PRINCIPAL_INVESTIGATOR) |
| University of Chicago | Chicago | Illinois | 60637 | Lou Philipson, MD, PhD (PRINCIPAL_INVESTIGATOR) Siri Greeley, MD, PhD (PRINCIPAL_INVESTIGATOR) |
| Indiana University | Indianapolis | Indiana | 46202 | Carmella Evans-Molina, MD, PhD (PRINCIPAL_INVESTIGATOR) |
| University of Maryland | Baltimore | Maryland | 21201 | Toni Pollin, PhD, MS (PRINCIPAL_INVESTIGATOR) |
| Massachusetts General Hospital (MGH) | Boston | Massachusetts | 02114 | Sara Cromer, MD (PRINCIPAL_INVESTIGATOR) |
| University of Michigan | Ann Arbor | Michigan | 48109 | Elif Oral, MD (PRINCIPAL_INVESTIGATOR) |
| Washington University in St. Louis | St Louis | Missouri | 63110 | Fumihiko Urano, MD, PhD (PRINCIPAL_INVESTIGATOR) |
| SUNY Downstate Health Sciences University | Brooklyn | New York | 11203 | Mary Ann Banerji, MD (PRINCIPAL_INVESTIGATOR) |
| Columbia University | New York | New York | 10032 | Robin Goland, MD (PRINCIPAL_INVESTIGATOR) |
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27514 | John Buse, MD, PhD (PRINCIPAL_INVESTIGATOR) |
| Vanderbilt University | Nashville | Tennessee | 37232 | Kevin Niswender, MD, PhD (PRINCIPAL_INVESTIGATOR) |
| Baylor College of Medicine | Houston | Texas | 77030 | Ashok Balasubramanyam, MD (PRINCIPAL_INVESTIGATOR) Maria Redondo, MD, PhD, MPH (PRINCIPAL_INVESTIGATOR) |
| University of Washington | Seattle | Washington | 98109 | Irl B Hirsch, MD (PRINCIPAL_INVESTIGATOR) |
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