Enhancing Innate Anti-Viral Resistance Through A Community-Based Intervention - Generation Xchange

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of California, Los Angeles
Study ID
NCT05534425
Status
Enrolling By Invitation

Conditions

  • Virus Infection, RNA

Eligibility Criteria

Sex
ALL
Age
50 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • GenX intergenerational mentoring program — BEHAVIORAL
    GenX trains older adults to collaborate with K-3rd grade teachers in mentoring high-need elementary school students in core reading and math skills.

Study Details

This randomized controlled trial will test whether a recently developed community-based intergenerational mentoring program known as Generation Xchange (GenX) can enhance antiviral resistance in older African-American women and men in a low-SES urban community. Additional studies will identify the biological processes that promote resistance to respiratory virus infections and viral disease in older African-American women and men.

Key Dates

Start date
Sep 26, 2022
Status verified
Aug 2025
Primary completion
Aug 31, 2027
Completion
Aug 31, 2027

Study Design

Enrollment
160 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Immediate GenX
    Participants immediately commence GenX program activity (intergenerational mentoring)
  • Active Comparator: Delayed GenX
    Participants engage in parallel training/educational activities, and subsequently commence GenX program activity after 3 months

Primary Outcome Measure

Concentration of Type I interferon antiviral activity (bioassay International Units / mL) [ Time Frame: 10 months ]

Locations (1)

FacilityCityStateZIPSite coordinators
UCLA School of MedicineLos AngelesCalifornia90095-

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By research site
UCLA School of Medicine· Los Angeles, CA