@neurIST : Intregrated Biomedical Informatics for the Management of Cerebral Aneurysms

Part of paid clinical trials in San Francisco, California.

Sponsor
University Hospital, Geneva
Study ID
NCT05526352
Status
Recruiting
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Conditions

  • Intracranial Aneurysm

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

The primary aim of the SwissNeuroFoundation AneurysmDataBase Project is to implement information technology based tools to create and use a holistic reference database specific to intracranial aneurysms (IA). The SwissNeuroFoundation AneurysmDataBase are concerned with generating the data with which to populate this database. The purpose for populating the database are to: * Screen for and evaluate markers of risk for intracranial aneurysm formation and aneurysm rupture. Are considered as markers the following: genetics factors, microbiota, environmental factors, congenital factors (ie: cerebrovascular anatomical variants), transcriptomics signature, proteomics signature,shape characteristics, haemodynamics characteristics. * Screen for and evaluate prognostic factors of outcome regarding different management strategies including watchful observation, microsurgical treatment, endovascular treatment or any combination thereof. * Implement and evaluate patient-specific management protocols integrating all available information. * Evaluate the impact of the database and use of tools to improve care, reduce costs, support knowledge discovery and promote new industrial developments.

Key Dates

Start date
Jun 1, 2015
Status verified
Jan 2026
Primary completion
Mar 1, 2040
Completion
Mar 1, 2040

Study Design

Enrollment
20,000 participants (estimated)

Arms

  • Arm: IA Patients
    Patients with one or more identified intracranial aneurysm, none of which are believed to have ruptured.
  • Arm: IA + SAH Patients
    Patients with one or more identified intracranial aneurysm, at least one of which has been radiologically or surgically determined to have ruptured.
  • Arm: Familiy members
    Individuals selected on review of a patient's family tree and contacted by said patient, who agree to be approached for recruitment. In affected families each member will be identified as: proband, affected, unaffected, unknown, or not genetically linked.
  • Arm: Healthy Volunteers
    Individuals, accompanying or contacted by a patient, or responding to open advertisement, or randomly selected in a defined population who agree to be approached for recruitment.

Primary Outcome Measure

Disease model validation [ Time Frame: 5 years ]

Central Contacts

Locations (3)

FacilityCityStateZIPSite coordinators
University of CaliforniaSan FranciscoCalifornia-
Nerissa Ko
University of Cincinnati College of MedicineCincinnatiOhio-
Joseph Broderick
Daniel Woo (SUB_INVESTIGATOR)
University of VirginiaVirginia BeachVirginia-
Bradford Worrall

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