Personalized Postoperative Pain Management Following Thoracic Surgery in Adults

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
OpalGenix, Inc
Study ID
NCT05525923
Status
Recruiting
Apply to this trial

Conditions

  • Lobectomy
  • Pneumonectomy
  • Segmentectomy
  • Thoracic Surgery

Eligibility Criteria

Sex
ALL
Age
18 Years - 99 Years
Healthy Volunteers
Not accepted

Study Details

The proposed research is an important extension of an ongoing perioperative personalized analgesia and intravenous opioid pharmacogenetic research. This research focuses on two of the most commonly used oral opioid analgesics, oxycodone, and methadone, in adults following thoracic surgery. Major inpatient thoracic surgeries (TS) for lung disease are common and extremely painful surgeries and are associated with sever post-surgical pain, high incidence of chronic post-surgical pain (CPSP), excess opioid use, costly immediate postoperative opioid adverse events (AEs), and long hospital stays. This study is aiming to develop proactive risk prediction algorithms for precision surgical pain relief in adult TS patients through comparison of actual clinical outcomes with standard of care to predicted outcomes based on personalized risk assessments.

Key Dates

Start date
Nov 30, 2023
Status verified
Apr 2025
Primary completion
Mar 1, 2026
Completion
Mar 1, 2028

Study Design

Enrollment
200 participants (estimated)

Primary Outcome Measure

Opioid-related Post-operative nausea and vomiting (PONV) [ Time Frame: Post-operative up to 12 months ]

Central Contacts

Locations (4)

FacilityCityStateZIPSite coordinators
UPMC Mercy HospitalPittsburghPennsylvania15219
Kathirvel Subramaniam, MD
[email protected]
Amy Monroe, MPH, MBA
[email protected]
412-623-6382
Kathirvel Subramaniam, MD (PRINCIPAL_INVESTIGATOR)
UPMC Passavant HospitalPittsburghPennsylvania15237
Kathirvel Subramaniam, MD
[email protected]
Amy Monroe, MPH, MBA
[email protected]
412-623-6382
Kathirvel Subramaniam, MD (PRINCIPAL_INVESTIGATOR)
UPMC Presbyterian HospitalPittsburghPennsylvania15213
Kathirvel Subramaniam, MD, MPH
[email protected]
Amy Monroe, MPH, MBA
[email protected]
412-623-6382
UPMC Shadyside HospitalPittsburghPennsylvania15232
Kathirvel Subramaniam, MD
[email protected]
Amy Monroe, MPH, MBA
[email protected]
412-623-6382
Kathirvel Subramaniam, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Pittsburgh, PA

By research site
UPMC Mercy Hospital· Pittsburgh, PAUPMC Passavant Hospital· Pittsburgh, PAUPMC Presbyterian Hospital· Pittsburgh, PAUPMC Shadyside Hospital· Pittsburgh, PA

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