Noninvasive Brain Stimulation to Enhance Reading Comprehension Ability in Adults

Part of paid clinical trials in Nashville, Tennessee.

Sponsor
Vanderbilt University
Study ID
NCT05523505
Status
Recruiting
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Conditions

  • Reading Disability

Eligibility Criteria

Sex
ALL
Age
18 Years - 40 Years
Healthy Volunteers
Accepted

Interventions

  • Sham intervention — DEVICE
    Use of the non-invasive brain stimulation device to simulate peripheral experience of stimulation without actually stimulating the brain.
  • RLN real non-invasive brain stimulation intervention — DEVICE
    Real non-invasive brain stimulation to the left angular gyrus using transcranial alternating current stimulation (tACS).
  • RLN and CCN real non-invasive brain stimulation intervention — DEVICE
    Real non-invasive brain stimulation to the left dorsolateral prefrontal cortex and left angular gyrus using transcranial alternating current stimulation (tACS).

Study Details

The goal of this project is to address the urgent need for effective, scalable adult literacy interventions by integrating breakthroughs in two separate fields: 1.) the brain network science of resilience to reading disorders and 2.) high-definition non-invasive brain network stimulation. This study will first establish the efficacy of a novel, noninvasive stimulation protocol on reading behavior and brain metrics; then will determine how stimulation-induced effects interact with baseline reading comprehension ability; and lastly, will identify whether stimulation-induced effects are more clinically-beneficial than canonical behavioral interventions. Results may change the foundation for how we treat low adult literacy, and have the potential for wider reaching impacts on non-invasive stimulation protocols for other clinical disorders.

Key Dates

Start date
Nov 7, 2022
Status verified
Jul 2025
Primary completion
Sep 10, 2026
Completion
Sep 10, 2026

Study Design

Enrollment
100 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Sham Comparator: Sham stimulation
    Participants receiving sham stimulation.
  • Experimental: Reading and Language Network (RLN)
    Participants receiving real stimulation to the left angular gyrus.
  • Experimental: RLN and CCN
    Participants receiving real stimulation to the left dorsolateral prefrontal cortex and left angular gyrus.

Primary Outcome Measure

Change in reading comprehension ability on standardized test measure [ Time Frame: Baseline to 12 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Vanderbilt University Medical CenterNashvilleTennessee37203
Katherine S. Aboud, PhD
[email protected]
615-322-2793

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By research site
Vanderbilt University Medical Center· Nashville, TN

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