Gene Expression in Lower Extremity Acute Traumatic Compartment Syndrome

Conditions

• Tibial Plateau Fracture
• Tibial Shaft Fracture

Eligibility Criteria

Sex

ALL

Age

18 Years - 90 Years

Healthy Volunteers

Not accepted

Interventions

• Acute injury without compartment syndrome — PROCEDURE
  Acute tibial shaft or tibial plateau fractures who do not have clinical compartment syndrome. Muscle punch biopsy of the anterior compartment will be taken.
• Acute injury with compartment syndrome — PROCEDURE
  Acute tibial shaft or tibial plateau fractures who have clinical compartment syndrome. Muscle punch biopsy of the anterior compartment will be taken.
• Exertional compartment syndrome — PROCEDURE
  For patients with exertional compartment syndrome, a muscle biopsy will be obtained from affected extremity.

Study Details

The purpose of this study is to evaluate both genotypic differences and differences in local gene expression in individuals who develop acute traumatic compartment syndrome relative to control patients with at-risk lower extremity fractures who do not develop compartment syndrome.

Key Dates

Start date

Jun 10, 2022

Status verified

Apr 2026

Primary completion

Jun 30, 2028

Completion

Jun 30, 2028

Study Design

Enrollment

80 participants (estimated)

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Arms

• Other: Acute tibial shaft or tibial plateau fractures without compartment syndrome
  Patients with acute lower leg fractures who do not have clinical compartment syndrome.
• Other: Acute tibial shaft or tibial plateau fractures with compartment syndrome.
  Patients with acute lower leg fractures with acute compartment syndrome.
• Other: Exertional compartment syndrome
  Patients with a diagnosis of exertional compartment syndrome who are planning to undergo surgical procedure to release the compartment fascia will be recruited to participate prior to surgical intervention.

Primary Outcome Measure

Myostatin (% increase) [ Time Frame: Immediately after the muscle tissue harvest procedure. ]

Locations (1)

Find similar trials in Salt Lake City, UT

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