TRPC6 Characterization to Predict and Prevent Chemotherapy Related Cardiomyopathy and Heart Failure With Breast Cancer

Part of paid clinical trials in Gainesville, Florida.

Sponsor
Mayo Clinic
Study ID
NCT05507879
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Biospecimen Collection — PROCEDURE
    Undergo collection of blood samples
  • Electronic Medical Record — OTHER
    Review of medical records

Study Details

This study examines TRPC6 in predicting and preventing chemotherapy related cardiac toxicity and heart failure in patients with breast cancer. Cardiac toxicity, changes in heart function is a well-recognized complication of certain cancer related therapies. Understanding these changes may allow early intervention against therapy-related cardiac toxicity and also identify novel therapeutic targets to protect patient long-term cardiac health. Studying samples of blood from patients with breast cancer in the laboratory may help doctors learn more about changes that occur in deoxyribonucleic acid (DNA), identify biomarkers related to cardiac toxicity, and prevent the development of therapy-induced cardiac toxicity in patients receiving chemotherapy.

Key Dates

Start date
Sep 26, 2022
Status verified
Feb 2026
Primary completion
Sep 1, 2026
Completion
Sep 1, 2027

Study Design

Enrollment
200 participants (estimated)

Arms

  • Arm: Ancillary-Correlative (biospecimen collection)
    Patients undergo collection of blood samples at time of therapy initiation. Patients who develop cardiac toxicity may undergo additional collection of blood samples. Patients' medical records are also reviewed.

Primary Outcome Measure

Significance ofTRPC6 coding sequencing [ Time Frame: Up to study completion, up to four years to completion. ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
University of FloridaGainesvilleFlorida32610
Katelyn Bruno, Ph.D.
[email protected]
352-273-8933
Katelyn Bruno, Ph.D. (PRINCIPAL_INVESTIGATOR)
Mayo Clinic in FloridaJacksonvilleFlorida32224-9980
Clinical Trial Referral Office
[email protected]
855-776-0015
Nadine Norton, Ph.D. (PRINCIPAL_INVESTIGATOR)

Find similar trials in Gainesville, FL

By condition
Breast cancerHeart failure
By specialty
OncologyBreast oncologyWomen's healthCardiologyHeart disease
By research site
University of Florida· Gainesville, FLMayo Clinic in Florida· Jacksonville, FL

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