Circulating Biomarkers in the Development of Type 1 Diabetes

Part of paid clinical trials in Duarte, California.

Sponsor
City of Hope Medical Center
Study ID
NCT05505669
Status
Recruiting
Apply to this trial

Conditions

  • Diabetes

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Accepted

Interventions

  • One-time blood (up to 100 ml) will be drawn and the amount of blood drawn is based on weight. Saliva and urine will be collected during the blood draw visit. — OTHER
    One-time blood (up to 100 ml) will be drawn and the amount of blood drawn is based on weight. Saliva and urine will be collected during the blood draw visit.

Study Details

More than 100 million U.S. adults are now living with diabetes or prediabetes. Investigators still do not fully understand how diabetes develops and how the disease worsens. Insulin is a hormone that helps the body use sugar as a fuel and control blood-sugar levels. People with diabetes have problems making insulin. This is because their insulin-producing beta cells -in the pancreas-are damaged or destroyed. A biomarker is a biological molecule (such as DNA, RNA (the genetic material of cells) or protein) that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker can be measured and found in blood and/or other body fluids (such as saliva and urine). Understanding the biology of beta cells could help find diabetes-related biomarkers. The discoveries from this research could help with early diagnosis of diabetes and lead to the creation of therapies for treating diabetes.

Key Dates

Start date
Mar 29, 2022
Status verified
Jan 2026
Primary completion
Jun 9, 2026
Completion
Jun 9, 2026

Study Design

Enrollment
165 participants (estimated)

Arms

  • Arm: Adults with type 1 diabetes
    Adults with type 1 diabetes
  • Arm: Adult healthy volunteers
    Adult healthy volunteers
  • Arm: Children with type 1 diabetes
    Children with type 1 diabetes
  • Arm: Adults with type 2 diabetes
    Adults with type 2 diabetes
  • Arm: Adults with high blood sugar
    Adults with high blood sugar
  • Arm: Those at risk of developing type 1 diabetes
    Those at risk of developing type 1 diabetes

Primary Outcome Measure

Identification of circulating biomarkers that correlate with beta cell death in type 1 diabetes compared to healthy controls [ Time Frame: Baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
City of Hope Medical CenterDuarteCalifornia91010
Study Coordinator
[email protected]
866-444-7538

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By research site
City of Hope Medical Center· Duarte, CA

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