The Impact of Surgical Technique on Circulating Tumor DNA in Stage I-III Non-Small Cell Lung Cancer

Part of paid clinical trials in Abington, Pennsylvania.

Sponsor
Thomas Jefferson University
Study ID
NCT05502523
Status
Recruiting
Apply to this trial

Conditions

  • Lung Non-Small Cell Carcinoma
  • Stage I Lung Cancer AJCC v8
  • Stage II Lung Cancer AJCC v8
  • Stage III Lung Cancer AJCC v8

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Pulmonary Artery-First Surgical Technique — PROCEDURE
    Undergo pulmonary artery first surgical technique
  • Biospecimen Collection — PROCEDURE
    Correlative studies

Study Details

This clinical trial compares the effect of pulmonary vein-first surgical technique to pulmonary artery-first surgical technique in decreasing circulating tumor cell deoxyribonucleic acid (ctDNA) in patients with stage I-III non-small cell lung cancer. Pulmonary vein first and pulmonary artery first surgical techniques are standard surgical techniques for the division of the blood vessels during lung resection surgery. Pulmonary vein-first surgical technique may reduce the risk of shedding tumor cells during surgery and influence long term overall survival.

Key Dates

Start date
Aug 31, 2022
Status verified
Jan 2026
Primary completion
Jan 1, 2027
Completion
Jan 1, 2029

Study Design

Enrollment
100 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Group I (pulmonary vein first approach procedure)
    Patients undergo pulmonary vein first approach surgical procedure on day of surgery.
  • Active Comparator: Group II (pulmonary artery first surgical procedure)
    Patients undergo pulmonary artery first approach surgical procedure on day of surgery.

Primary Outcome Measure

Circulating tumor deoxyribonucleic acid (ctDNA) status [ Time Frame: At postoperative day 2 ]

Central Contacts

Locations (4)

FacilityCityStateZIPSite coordinators
Abington Memorial HospitalAbingtonPennsylvania19001
Mary Walicki, RN
[email protected]
215-481-5528
Jefferson Health NortheastPhiladelphiaPennsylvania19107
Joanne Anderson
215-866-8690
Thomas Jefferson University HospitalPhiladelphiaPennsylvania19107
Tyler Grenda, MD
[email protected]
215-955-5562
Asplundh Cancer Pavilion at Jefferson HealthWillow GrovePennsylvania19090
John Jacob, MD
215-481-4000

Find similar trials in Abington, PA

By research site
Abington Memorial Hospital· Abington, PAJefferson Health Northeast· Philadelphia, PAThomas Jefferson University Hospital· Philadelphia, PAAsplundh Cancer Pavilion at Jefferson Health· Willow Grove, PA

Related Studies