JAB-2485 Activity in Adult Patients With Advanced Solid Tumors

Part of paid clinical trials in Detroit, Michigan.

Sponsor
Jacobio Pharmaceuticals Co., Ltd.
Study ID
NCT05490472
Phase
PHASE1/PHASE2
Status
Recruiting
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Conditions

  • ARID1A Gene Mutation
  • ER+ Breast Cancer
  • Small Cell Lung Cancer, SCLC
  • Solid Tumors
  • Triple Negative Breast Cancer, TNBC

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • JAB-2485 (Aurora A inhibitor) — DRUG
    Administered orally
  • JAB-2485 (Aurora A inhibitor) — DRUG
    Administered orally

Study Details

This study is to evaluate the safety and tolerability of JAB-2485 monotherapy in adult participants with advanced solid tumors.

Key Dates

Start date
Dec 20, 2022
Status verified
Nov 2025
Primary completion
Aug 31, 2026
Completion
Aug 31, 2027

Study Design

Enrollment
102 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: JAB-2485 monotherapy, Phase 1, Dose Escalation
    Dose escalation of JAB-2485 will be administered as monotherapy to determine the MTD and RP2D.
  • Experimental: JAB-2485 monotherapy, Phase 2a, Dose Expansion
    JAB-2485 will be administered as monotherapy in patients with specific tumor types to evaluate the preliminary antitumor activity.

Primary Outcome Measure

Dose Escalation phase: Number of participants with dose limiting toxicities (DLTs) [ Time Frame: First 21 days of Cycle 1 ]

Central Contacts

Locations (4)

FacilityCityStateZIPSite coordinators
Henry Ford Health SystemDetroitMichigan48202-
Washington UniversitySt LouisMissouri63110-
Mary Crowley Cancer ResearchDallasTexas75230-
University of Utah Huntsman Cancer InstituteSalt Lake CityUtah84112-

Find similar trials in Detroit, MI

By research site
Henry Ford Health System· Detroit, MIWashington University· St Louis, MOMary Crowley Cancer Research· Dallas, TXUniversity of Utah Huntsman Cancer Institute· Salt Lake City, UT

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