The Effect of NAD Supplementation on Brain Vascular Health in Aging

Part of paid clinical trials in Oklahoma City, Oklahoma.

Sponsor
University of Oklahoma
Study ID
NCT05483465
Phase
PHASE4
Status
Recruiting
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Conditions

  • Aging

Eligibility Criteria

Sex
ALL
Age
60 Years - 85 Years
Healthy Volunteers
Accepted

Interventions

  • Nicotinamide riboside — DRUG
    Oral NR, 1g/day per os for 8 weeks
  • Placebo — DRUG
    Visually identical pill to NR, daily per os for 8 weeks

Study Details

Daily consumption of one of the forms of Vitamin B3, the Nicotinamide Riboside (NR), energizes the body and combats cellular aging. This study is designed to test whether NR can also improve brain health and memory.

Key Dates

Start date
May 3, 2023
Status verified
Mar 2026
Primary completion
Jun 30, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
214 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Experimental: NR
    Treatment with oral NR (1g/day per os for 8 weeks)
  • Placebo Comparator: Control
    Visually identical placebo (daily, per os, for 8 weeks)

Primary Outcome Measure

Change in neurovascular coupling using functional near infrared spectroscopy (fNIRS) [ Time Frame: 8 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Oklahoma Health Sciences CenterOklahoma CityOklahoma73117
Andriy Yabluchanskiy, MD, PhD
[email protected]
405-271-8130
Peter Mukli, MD, PhD
[email protected]
405-271-8000

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By research site
University of Oklahoma Health Sciences Center· Oklahoma City, OK

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