Spinal Cord Stimulation and Training

Part of paid clinical trials in St Louis, Missouri.

Sponsor
Washington University School of Medicine
Study ID
NCT05472584
Status
Recruiting
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Conditions

  • Spinal Cord Injuries

Eligibility Criteria

Sex
ALL
Age
16 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • Electrophysiology assessment - corticospinal tract — OTHER
    Kinematics and cortical spinal motor excitability
  • Electrophysiology assessment - reticulospinal tract — OTHER
    Kinematics and reticular spinal motor excitability
  • Electrophysiology assessment - spinal motoneuron — OTHER
    Kinematics and spinal motoneuron excitability
  • Activity-based training — OTHER
    Motor task
  • Transcutaneous spinal cord stimulation — OTHER
    Non-invasive spinal cord stimulation

Study Details

This study will help the investigators better understand the changes in short-term excitability and long-term plasticity of corticospinal, reticulospinal and spinal neural circuits and how the changes impact the improvements of spinal cord stimulation (SCS) mediated motor function.

Key Dates

Start date
Jul 21, 2023
Status verified
Mar 2026
Primary completion
Aug 31, 2027
Completion
Aug 31, 2027

Study Design

Enrollment
120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Experimental: Non-invasive spinal cord stimulation
    This arm will receive 30 minutes of transcutaneous spinal cord stimulation as participants rest.
  • Experimental: Experimental: Activity-based training
    This arm will perform 30 minutes of activity-based training using leg movements.
  • Experimental: Experimental: Activity-based training wtih non-invasive spinal cord stimulation
    This arm will receive transcutaneous spinal cord stimulation as participants perform 30 minutes of activity-based training using leg movements.
  • Experimental: Experimental: Non-invasive spinal cord stimulation and strength training
    This arm will receive transcutaneous spinal cord stimulation as participants perform strengthening exercises.
  • Experimental: Experimental: Non-invasive spinal cord stimulation and precision training
    This arm will receive transcutaneous spinal cord stimulation as participants perform precision-control and dexterity exercises.
  • Experimental: Experimental: Long-term activity-based training with non-invasive spinal cord stimulation
    This arm will receive 4 weeks of activity-based training with transcutaneous spinal cord stimulation

Primary Outcome Measure

Motor evoked potentials amplitude and latency [ Time Frame: 30 minutes before and 30 minutes after intervention; 4 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Washington UniversitySt LouisMissouri63130
Ismael Seanez, PHD
[email protected]
314-935-7665

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By research site
Washington University· St Louis, MO

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