The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active Adults

Part of paid clinical trials in Norfolk, Virginia.

Sponsor
Old Dominion University
Study ID
NCT05468255
Status
Recruiting
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Conditions

  • Exercise
  • Glucose Intolerance
  • Vascular Function

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Accepted

Interventions

  • removal of exercise — OTHER
    Subjects will stop doing their normal exercise routines for 3 or 5 days and then subjects will resume doing their normal exercise routines for 3 days.

Study Details

The purpose of this study is to determine if an acute bout of removal of exercise reduces enothelial function and glycemic control in an active, older adult population; and whether a 3 day return to exercise restores this response. Glycemic control is the blood glucose response following the consumption of a meal. It is an indicator of insulin resistance (or type 2 diabetes) and impaired glycemic control has been suggested to lead to cardiovascular disease. Endothelial function has been shown to be improved by chronic or acute increases in physical activity. Both of these have been shown to be impaired to acute bouts of inactivity in young populations; however the impact of acute inactivity in older adults is less understood. In this proposal the investigators will examine 1)how quickly impairments in glycemic control occur to acute physical inactivity in older adults who exercise, 2) how quickly impairments in endothelial function occur to acute inactivity in older adults who exercise, and 3) whether 3 days of a return to exercise restores these responses.

Key Dates

Start date
Jul 25, 2022
Status verified
Apr 2024
Primary completion
Jan 30, 2025
Completion
Apr 1, 2025

Study Design

Enrollment
40 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Metabolic
    Metabolic: Participants will have their blood glucose levels measured via continuous glucose monitoring for 3 days while participating in their normal exercise routines (EX). Participants will also have their blood glucose levels measured for 3 days while not exercising (NOEX), following immediately by 3 days of a return to normal activity(REX). Participants will be randomized to participate in the EX or NOEX/REX phases first. The EX and NOEX/REX phases will be separated by at least 1 week
  • Experimental: Vascular
    Vascular: Participants will have their blood vessel health measured while performing their normal exercise routines (EX) and while undergoing 1, 3, 5 days of no exercise (NOEX) followed immediately by 1 and 3 days of return to exercise (REX).

Primary Outcome Measure

Continuous glucose monitoring [ Time Frame: 3 days before removal of exercise ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Old Dominion UniversityNorfolkVirginia23529
Leryn J Reynolds
[email protected]
757-683-4974

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By research site
Old Dominion University· Norfolk, VA

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