Depression and Driving

Conditions

F 18 AV-1451 (Flortaucipir) — DRUG
A dosage range between 6.5 - 10.0 mCi (240-370MBq) is planned for \[18F\] AV-1451. A PET-certified medical professional will prepare and administer the \[18F\] AV-1451tracer. Prior to the administration, the dosage will be assayed in a dose calibrator. The volume of 18F-AV-1451 dose should not be adjusted by adding normal saline to the syringe. Participants will receive a maximum intravenous bolus injection of 10.0 mCi of \[18F\] AV-1451 followed by a 10 mL flush of 0.9% sodium chloride (normal saline).
[11C]-Pittsburgh Compound B ([11C]PiB) — DRUG
A dosage range between 6.0 - 20.0 mCi (222-740 MBq) is planned for \[11C\] PIB. A PET-certified medical professional will prepare and administer the \[11C\] PIB tracer. Prior to the administration, the dosage will be assayed in a dose calibrator and diluted with 0.9% sodium chloride (normal saline) up to a total 20 mL syringe volume. Participants will receive a maximum intravenous bolus injection of 20.0 mCi of \[11C\] PIB followed by a 10 mL 0.9% sodium chloride (normal saline) flush.

This project will assess how depression, preclinical AD, and antidepressants affect driving behavior in cognitively normal older adults (65 years).

Arm: depression
All participants will receive two one time PET scans with tracers AV1451 and PIB to detect tau and amyloid in the brain.
Arm: control
All participants will receive two one time PET scans with tracers AV1451 and PIB to detect tau and amyloid in the brain.

Latitude via DRIVES chip [ Time Frame: Daily for up to five years ]

Facility	City	State	ZIP	Site coordinators
Washington University School of Medicine	St Louis	Missouri	63110	Kaylin Taylor, MA [email protected] 314-273-3573 Beau Ances, MD, PhD [email protected] (314)747-8423

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