Neural Connectivity During Therapy for Adolescent PTSD

Part of paid clinical trials in San Antonio, Texas.

Sponsor
The University of Texas Health Science Center at San Antonio
Study ID
NCT05423444
Status
Recruiting
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Conditions

  • Adolescent
  • PTSD
  • Psychological Trauma

Eligibility Criteria

Sex
ALL
Age
12 Years - 17 Years
Healthy Volunteers
Not accepted

Interventions

  • TF-CBT — BEHAVIORAL
    evidence-based psychotherapy for trauma in youth
  • TAU — BEHAVIORAL
    treatment as usual

Study Details

Posttraumatic stress disorder in adolescence impairs neurobiological networks underlying cognitive, social and emotional skills. Neuroimaging research that seeks to identify the neural mechanisms of treatments for PTSD could lead to novel treatments, but progress has been slow using current methods. The proposed study uses an innovative approach to identify neural mechanisms of specific phases of trauma-focused therapy for youth with PTSD, allowing a new understanding of brain changes associated with the process of therapy.

Key Dates

Start date
Nov 29, 2022
Status verified
Jan 2026
Primary completion
Feb 28, 2027
Completion
Feb 28, 2027

Study Design

Enrollment
180 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Trauma-focused cognitive behavioral therapy (TF-CBT)
    Trauma-focused Cognitive Behavioral Therapy (TF-CBT) is an evidence-based psychotherapy that is considered the gold-standard treatment for trauma in youth. The TF-CBT model is flexible but it follows a specific order of phases and components, including psychoeducation, emotion regulation skills, processing the trauma narrative, and safety planning. Sessions are provided weekly for 18-weeks.
  • Active Comparator: Treatment As Usual (TAU)
    Treatment as usual (TAU) consists of the standard-of-care psychotherapy as provided by licensed clinicians at a local clinic. The order and choice of techniques is based on the knowledge and preferences of the clinicians. Sessions are provided weekly for 18-weeks.

Primary Outcome Measure

Mean intensity within functional connectivity map of intrinsic network [ Time Frame: week 0 (baseline) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UT Health Department of PsychiatrySan AntonioTexas78229
Amy Garrett, PhD
[email protected]
2105678189

Find similar trials in San Antonio, TX

By condition
PTSD (post-traumatic stress disorder)
By specialty
PsychiatryMental healthBehavioral health
By research site
UT Health Department of Psychiatry· San Antonio, TX

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