The Effect of Hyperoxia on Ventilation During Recovery From General Anesthesia

Part of paid clinical trials in Stanford, California.

Sponsor
Stanford University
Study ID
NCT05379673
Status
Recruiting
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Conditions

  • Postoperative Respiratory Failure
  • Ventilatory Depression

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Not accepted

Interventions

  • Oxygen Gas for Inhalation — OTHER
    Oxyhemoglobin saturation (SpO2) higher than 96% vs SpO2 between 90% and 94%.

Study Details

In this randomized-controlled trial the investigators will examine the effect of oxygen supplementation on the recovery of breathing for 90 minutes in the immediate post-anesthesia period starting from extubation of the trachea.

Key Dates

Start date
Oct 4, 2022
Status verified
May 2025
Primary completion
Jul 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Active Comparator: "Conservative O2 Supplementation"
    Oxygen administration will be titrated to a oxyhemoglobin saturation (SpO2) between 90 and 94%.
  • Experimental: "Liberal O2 Supplementation"
    Oxygen administration will be titrated to an SpO2 \> 96%.

Primary Outcome Measure

Transcutaneous partial pressure of carbon dioxide (TcPCO2) [ Time Frame: Ninety -minute period beginning immediately post-anesthesia. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Stanford University School of MedicineStanfordCalifornia94305
Anthony Doufas, MD, PhD
[email protected]
(650) 498-7699
Anthony Doufas, MD, PhD (PRINCIPAL_INVESTIGATOR)

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Stanford University School of Medicine· Stanford, CA