European Prospective Investigation Into Childhood Cancer

Conditions

• Acute Lymphoblastic Leukemia
• Brain Tumor

Eligibility Criteria

Sex

ALL

Age

3 Years - 21 Years

Healthy Volunteers

Not accepted

Interventions

• Observational — OTHER
  No intervention

Study Details

Over the last decades, research has shown that poor nutritional status can adversely impact prognosis and increase toxicities during treatment for childhood cancer. EPICkids is a collaboration between the International Initiative for Pediatrics and Nutrition, the International Agency for Research on Cancer, and sites throughout three Southern European countries (Spain, Greece, and Italy). The primary aim of EPICkids is to establish an informational resource on critical nutrition parameters wherein we can describe the trajectory of nutritional status among Southern European children and adolescents with acute lymphoblastic leukemia (ALL) and favorable biology brain tumors, investigate lifestyle behaviors, sociodemographic factors, and quality of life and correlate these indicators with clinical outcomes. The specimens obtained with the proposed study will foster future studies on nutrition and prevalent childhood cancer as well as establish a framework to develop evidence-based guidelines for European children with cancer, utilizing regional, European data. We plan to recruit 900 patients with ALL and 1400 patients with a favorable biology brain tumor over five years. Nutrition parameters and lifestyle factors will be measured at systematic timepoints over the study period. Stool and blood specimens will be collected at each timepoint. Eligible patients will be between 3 and 21 years of age.

Key Dates

Start date

Jul 7, 2023

Status verified

May 2026

Primary completion

Mar 1, 2028

Completion

Mar 1, 2031

Study Design

Enrollment

1,400 participants (estimated)

Arms

• Arm: Acute lymphoblastic leukemia cohort
• Arm: Brain tumor cohort

Primary Outcome Measure

Evaluate the association of dietary and lifestyle variables to examine the association of nutritional status and dietary intake with side-effects from treatment and survival in children and adolescents with ALL and favorable biology brain tumors. [ Time Frame: From diagnosis to 1 year post-end of treatment ]

Central Contacts

• Michelle Walters
  2128514995
  [email protected]

Locations (1)

Find similar trials in New York, NY

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