Recording of Intraoperative Spinal Cord Stimulation and Monitoring

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of California, Los Angeles
Study ID
NCT05356286
Status
Recruiting
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Conditions

  • Cervical Stenosis
  • Disk, Herniated
  • Spondylosis

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • epidural electrical stimulation — DEVICE
    Electrical spinal cord stimulation will be used to modulate respiratory function during general anesthesia.

Study Details

Opioid overdose suppresses brainstem respiratory circuits, causes apnea, and may result in death. Epidural electrical stimulation (EES) at the cervical spinal cord facilitated motor activity in rodents and humans, and we hypothesized that EES of the cervical spinal cord could antagonize opioid-induced respiratory depression in humans. In this study, we will stimulate the spinal cord during surgery and assess its effects on respiratory function in human patients.

Key Dates

Start date
Jan 21, 2011
Status verified
Mar 2025
Primary completion
Jan 22, 2027
Completion
Jan 22, 2027

Study Design

Enrollment
150 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Electrical Stimulation group
    Epidural Electrical Stimulation of the Cervical Spinal Cord

Primary Outcome Measure

Change in respiratory frequency [ Time Frame: During intraoperative surgery during stimulation and within 2 minutes after stimulation ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of California, Los AngelesLos AngelesCalifornia90095
Daniel Lu, MD
[email protected]
310-825-4321

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By research site
University of California, Los Angeles· Los Angeles, CA

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