Optimizing Pulsatility During Cardiopulmonary Bypass

Part of paid clinical trials in Aurora, Colorado.

Sponsor
University of Colorado, Denver
Study ID
NCT05344573
Status
Recruiting
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Conditions

  • Acute Kidney Injury
  • Endothelial Dysfunction

Eligibility Criteria

Sex
ALL
Age
50 Years - 70 Years
Healthy Volunteers
Not accepted

Study Details

Cardiopulmonary bypass during cardiac surgery provides blood flow to the body during surgery but has adverse effects on different organs. Blood flow during cardiopulmonary bypass may be pulsatile or non-pulsatile, which may impact normal organ function after surgery. The study will collect data on the type of cardiopulmonary bypass used during surgery and organ function to determine if there is an association between the type of bypass and organ function.

Key Dates

Start date
Jul 5, 2022
Status verified
Nov 2024
Primary completion
Dec 1, 2024
Completion
Jul 1, 2025

Study Design

Enrollment
66 participants (estimated)

Arms

  • Arm: Non-pulsatile cardiopulmonary bypass
    Subjects who undergo cardiac surgery with non-pulsatile cardiopulmonary bypass
  • Arm: Pulsatile cardiopulmonary bypass
    Subjects who undergo cardiac surgery with pulsatile cardiopulmonary bypass

Primary Outcome Measure

Endothelial function [ Time Frame: From intensive care unit admission after surgery to hospital discharge, up to 30 days ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Colorado HospitalAuroraColorado80045
Nathan Clendenen, MD MS
[email protected]
303-724-5000
Nathan J Clendenen, MD MS (PRINCIPAL_INVESTIGATOR)

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By research site
University of Colorado Hospital· Aurora, CO

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