Glutamatergic Adaptation to Stress as a Mechanism for Anhedonia and Treatment Response With Ketamine

Part of paid clinical trials in Atlanta, Georgia.

Sponsor
Emory University
Study ID
NCT05327699
Phase
EARLY_PHASE1
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • Ketamine — DRUG
    A single intravenous (IV) infusion of ketamine calculated at 0.5mg/kg through an indwelling catheter over a 40-100min period.
  • Placebo — OTHER
    A single intravenous (IV) infusion of saline through an indwelling catheter over a 40-100min period.

Study Details

The main purpose of this study is to investigate the effects of ketamine on decision-making and emotion processing in a sample of individuals diagnosed with Major Depressive Disorder (MDD).

Key Dates

Start date
Nov 8, 2022
Status verified
May 2026
Primary completion
Mar 2, 2028
Completion
Mar 2, 2028

Study Design

Enrollment
140 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Experimental: Major depressive disorder (MDD) Ketamine
    Participants randomized to the ketamine arm will receive a single intravenous (IV) infusion of ketamine at 0.5mg/kg through an indwelling catheter over a 40-100min period.
  • Placebo Comparator: Major depressive disorder (MDD) Placebo
    Participants randomized to the placebo arm will receive a single intravenous (IV) infusion of saline through an indwelling catheter over a 40-100min period.
  • No Intervention: Healthy Controls
    The subjects in this group will not receive any intervention.

Primary Outcome Measure

Change in glutamate concentration in the medial prefrontal cortex (mPFC) [ Time Frame: Baseline, 24 hours post-infusion, 14 days post-infusion ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Emory UniversityAtlantaGeorgia30322
Michael Treadway, PhD
[email protected]
(404) 727-7541
Michael Treadway, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Atlanta, GA

By condition
Depression
By specialty
PsychiatryMental healthBehavioral health
By research site
Emory University· Atlanta, GA

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