Sympathetic Mechanisms in Obesity-Crossover Design

Conditions

• Hypertension
• Obesity

Eligibility Criteria

Sex

ALL

Age

18 Years - 65 Years

Healthy Volunteers

Not accepted

Interventions

• Amlodipine — DRUG
  Subjects will receive either an antihypertensive (amlodipine or moxonidine) medication or placebo for two weeks, then cross over to the second arm, and then after 2 weeks of the second drug/placebo, will be switched to the third arm.
• Moxonidine — DRUG
  Moxonidine
• Placebo — DRUG
  Placebo

Study Details

We will study obese hypertensive subjects in a randomized, crossover study to determine if two weeks sympathetic blockade improves endogenous glucose production. Subjects will be studied on 3 different occasions after two weeks of receiving either placebo, amlodipine (vasodilator arm) or moxonidine (study arm). The order of the studies will be determined using computer-generated randomization. Patients will be blinded as to which treatment they are receiving on each day. An investigator blinded to the treatment assignment will perform the analysis of the data.

Key Dates

Start date

May 20, 2022

Status verified

Feb 2026

Primary completion

Dec 31, 2028

Completion

Dec 31, 2030

Study Design

Enrollment

12 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Arms

• Placebo Comparator: Placebo
  Subjects will received 2 weeks of capsules containing placebo.
• Active Comparator: Amlodipine
  Subjects will received 2 weeks of capsules containing amlodipine.
• Experimental: Moxonidine
  Subjects will received 2 weeks of capsules containing moxonidine.

Primary Outcome Measure

Endogenous glucose production [ Time Frame: During two-step insulin clamp (six hours) ]

Locations (1)

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