Habitat Escalated Adaptive Therapy (HEAT), With Neoadjuvant Radiation for Soft Tissue Sarcoma

Conditions

Intensity Modulated Radiation Therapy (IMRT) — RADIATION
Participants will be treated with intensity modulated radiation therapy (IMRT) with photons, which is FDA (U.S. Food and Drug Administration) approved radiation delivery system.
MRI — DIAGNOSTIC_TEST
Participants will receive pretreatment diagnostic MRIs to generate MRI habitats. These images will identify radioresistant cells within tumor.

The purpose of the study is to utilize radiomic images to precisely locate areas of tumor that can be treated with dose escalation radiation therapy.

Experimental: Treatment
Participants will receive pretreatment diagnostic MRIs to generate MRI habitats (images of tumor regions/subregions in different sequences). These images will identify radioresistant cells within the tumor to allow for more precise and higher doses of radiation to the resistant cells. Participants will then be treated with neoadjuvant external beam radiation by using the intensity modulated radiation (IMRT) technique, with dose painting (simultaneous integrated boost/SIB) to 70 Gray Units (Gy), 60 Gy, and 50 Gy in 25 fractions for habitats 1, 2, and 3, respectively.

Rate of Favorable Pathologic Response (FPR) [ Time Frame: Week 10 ]

Facility	City	State	ZIP	Site coordinators
Moffitt Cancer Center	Tampa	Florida	33612	Arash O Naghavi, MD, MS (PRINCIPAL_INVESTIGATOR) Marilyn Bui, MD, PhD (SUB_INVESTIGATOR) Ricardo Gonzalez, PhD (SUB_INVESTIGATOR) Nainesh Parikh, MD, MBA (SUB_INVESTIGATOR)

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