Investigating Targetable Metabolic Pathways Sustaining Pancreatic Cancer

Part of paid clinical trials in Livingston, New Jersey.

Sponsor
Rutgers, The State University of New Jersey
Study ID
NCT05296421
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Biopsy — PROCEDURE
    Undergo biopsy
  • Therapeutic Conventional Surgery — PROCEDURE
    Undergo surgery
  • Uniformly-labeled [13C]glucose — OTHER
    Given IV

Study Details

This clinical trial investigates the nutrients pancreatic cancers depend on in which to survive and the processes these tumors use (metabolism) to obtain these nutrients. Giving U-13C-glucose during surgery may allow doctors to trace the metabolic activity of pancreatic cancer in research experiments done in the laboratory. These experiments may help researchers understand how cancer cells manage their nutrients when compared to normal pancreatic cells.

Key Dates

Start date
Mar 14, 2022
Status verified
Apr 2026
Primary completion
Mar 1, 2027
Completion
Jul 1, 2027

Study Design

Enrollment
16 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Basic science (uniformly-labeled [13C]glucose)
    Patients receive uniformly-labeled \[13C\]glucose IV over 10 minutes and then over up to 120 minutes until time of biopsy. Patients then undergo surgery and biopsy per standard of care.

Primary Outcome Measure

To measure glycolysis metabolism dependencies via liquid chromatography-mass spectrometry (LC-MS) [ Time Frame: Up to 2 years ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Cooperman Barnabas Medical Center (Saint Barnabas Medical Center)LivingstonNew Jersey07039-
Rutgers Cancer Institute of New JerseyNew BrunswickNew Jersey08903
Howard S. Hochster
732-235-5912
Howard S. Hochster (PRINCIPAL_INVESTIGATOR)

Find similar trials in Livingston, NJ

By condition
Pancreatic cancer
By specialty
OncologyGI oncology
By research site
Cooperman Barnabas Medical Center (Saint Barnabas Medical Center)· Livingston, NJRutgers Cancer Institute of New Jersey· New Brunswick, NJ

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