Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

Part of paid clinical trials in Gainesville, Florida.

Sponsor
University of Florida
Study ID
NCT05277025
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Accepted

Study Details

Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome. Rheumatoid arthritis (RA) is characterized by polyarthritis and pain from inflamed tissues, consistent with nociceptive pain. FM and RA patients may utilize overlapping pain mechanisms resulting in nociceptive and nociplastic pain.

Key Dates

Start date
Mar 22, 2022
Status verified
Jun 2025
Primary completion
Feb 28, 2027
Completion
Feb 28, 2027

Study Design

Enrollment
150 participants (estimated)

Arms

  • Arm: Fibromyalgia
    Participants who fulfill the 1990 and 2011 American College of Rheumatology Criteria for FM.
  • Arm: Rheumatoid Arthritis
    Participants who fulfill the 2010 American College of Rheumatology (ACR)-European League against rheumatism (EULAR) classification criteria for RA.
  • Arm: Healthy Volunteers
    Participants who do not have significant pain/fatigue/anxiety/depression.

Primary Outcome Measure

Pressure Pain Thresholds [ Time Frame: One hour ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of FloridaGainesvilleFlorida32610
Melyssa Godfrey
[email protected]
352-265-8901
Roland Staud, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Gainesville, FL

By condition
Rheumatoid arthritis
By specialty
RheumatologyAutoimmune diseaseMusculoskeletal disorders
By research site
University of Florida· Gainesville, FL

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