Utilization of a Videoscope in Periodontal Regeneration

Conditions

• Chronic Periodontitis

Eligibility Criteria

Sex

ALL

Age

18 Years - 70 Years

Healthy Volunteers

Accepted

Interventions

• Videoscope-assisted periodontal regeneration minimally invasive surgery — DEVICE
  Use of a videoscope to improve visualization of periodontal defect during minimally invasive surgery
• Periodontal regeneration minimally invasive surgery — PROCEDURE
  Conventional periodontal regeneration minimally invasive surgery without use of a videoscope
• Guided tissue regeneration surgery — PROCEDURE
  Conventional guided tissue regeneration surgery for periodontal regeneration without use of a videoscope

Study Details

Clinical and preclinical studies confirm that regeneration of supporting tissues of teeth lost due to periodontal disease can be achieved using the principles of minimally invasive surgery (MIS). Although this therapeutic approach is well established in clinical settings and can rescue teeth with poor or questionable prognosis, MIS approaches often suffer from lack of predictability due to poor intraoral visibility of the bony lesion and inability to confirm thorough removal of etiological factors (plaque/calculus) on tooth surfaces. We seek to investigate whether improved visualization of the surgical field using an FDA approved videoscope (V) improves clinical outcomes. For this pilot study, N=50 (to attain 10/group) age, sex matched, systemically healthy subjects diagnosed with Stage III, Grade B periodontitis, formerly known as severe chronic periodontitis, will be randomly assigned to either the VMIS (Test), MIS (Control 1) or Guided Tissue Regeneration (GTR, Control 2) group. All periodontal therapy will be performed following the Standard of Care for periodontal regeneration to determine if utilization of the videoscope improves clinical and radiographic outcomes. We will examine bone fill using conventional digital periapical radiographs (PAR) and Cone Beam Computed Tomography (CBCT) imaging at 6 and 12 months compared to baseline and collect gingival crevicular fluid (GCF) to compare expression of growth factors and cytokines/chemokines during the healing period. This is a single center treatment study where subjects will be recruited from individuals seeking periodontal treatment at the Graduate Periodontics Clinic, UIC College of Dentistry (COD). Participation of all subjects will end after 12 months and will comprise 7 total visits.

Key Dates

Start date

May 1, 2022

Status verified

Dec 2024

Primary completion

Apr 30, 2026

Completion

Dec 31, 2026

Study Design

Enrollment

50 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Videoscope-assisted periodontal regeneration minimally invasive surgery
  Videoscope-assisted periodontal regeneration minimally invasive surgery - Test group
• Active Comparator: Periodontal regeneration minimally invasive surgery
  Periodontal regeneration minimally invasive surgery - Control Group 1
• Active Comparator: Guided tissue regeneration surgery
  Guided tissue regeneration - Control Group 2

Primary Outcome Measure

Clinical Attachment Level [ Time Frame: 6 months ]

Central Contacts

• Salvador Nares, DDS, PhD
  312-413-5787
  [email protected]

Locations (1)

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