Investigating the Mechanisms of the Effects of Psilocybin on Visual Perception and Visual Representations in the Brain

Conditions

• Perception Disorders

Eligibility Criteria

Sex

ALL

Age

21 Years - N/A

Healthy Volunteers

Accepted

Interventions

• Psilocybin — DRUG
  The effects of different doses of psilocybin (0 - 14 mg) will be compared.

Study Details

The long-term objective of this project is to characterize how psilocybin affects visual perception and the brain's representation of the visual environment. It is known that psilocybin alters aspects of visual perception, but the underlying brain mechanisms contributing to these effects are poorly understood. The proposed work will address these questions in a large, diverse sample of healthy human subjects by using functional magnetic resonance imaging (fMRI) to measure the brain's responses to visual stimuli. The proposed research will document which brain areas mediate the effects of psilocybin. The technique of fMRI will be employed to measure brain activity in different brain areas while subjects are performing a visual perceptual task.

Key Dates

Start date

Mar 8, 2024

Status verified

Oct 2025

Primary completion

Dec 31, 2025

Completion

Dec 31, 2025

Study Design

Enrollment

80 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Experimental
  Psilocybin 0-14 mg, before fMRI measurement
• Other: Comparator
  Psilocybin 0-14 mg, before fMRI measurement

Primary Outcome Measure

Amplitude and pattern of fMRI cortical responses [ Time Frame: Functional MRI recordings will begin approximately 30 minutes after oral administration of experimental or comparator arm treatment and will continue for up to two hours. ]

Central Contacts

• BCSP Staff
  (669) 244-2436
  [email protected]

Locations (1)

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