Stress Phenotypes and Preterm Birth

Part of paid clinical trials in New York, New York.

Sponsor
Columbia University
Study ID
NCT05229666
Status
Recruiting
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Conditions

  • Inflammation
  • Mental Health Issue
  • Preterm Birth
  • Stress

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Cognitive Challenge — OTHER
    A cognitive challenge (Stroop Color-Word Test) administered at 36-38 weeks gestation to assess fetal heart rate reactivity in response to maternal acute stress.

Study Details

Pregnancy ends in preterm birth (PTB) for approximately 1 in 10 women, though more often for Non-Hispanic Black women, 14.12% PTB rate, compared to 9.09% for Non-Hispanic White women. Psychosocial stress and childhood trauma each are associated with risk for PTB and PTB has an intergenerational impact: mothers born preterm are more likely to give birth preterm, especially amongst Black women. In this project, we will study mitochondria, which contain their own genome, the mitochondria DNA, and are inherited from the mother, as they represent a potential intersection point between psychosocial experiences and their biological embedding in underlying disease outcomes such as PTB

Key Dates

Start date
Dec 9, 2021
Status verified
May 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2027

Study Design

Enrollment
200 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Other: Cognitive Challenge
    A cognitive challenge (Stroop Color-Word Test) administered at 36-38 weeks gestation to assess fetal heart rate reactivity in response to maternal acute stress.

Primary Outcome Measure

Higher percentage of Black and Hispanic women in high stress group [ Time Frame: At 12 - 38 weeks gestation ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Columbia University Irving Medical CenterNew YorkNew York10032
Catherine Monk, PhD
[email protected]
917-543-6031

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By research site
Columbia University Irving Medical Center· New York, NY

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