Risk of Mental Health Conditions in Children and Young Adults With Inflammatory Bowel Disease and Influence on Health

Sponsor
Momentum Data
Study ID
NCT05206734
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
5 Years - 25 Years
Healthy Volunteers
Accepted

Interventions

  • No specific intervention — OTHER
    Observational analysis of usual care only.

Study Details

This study is a large population-based analysis in the United Kingdom (UK) using routine primary care data to investigate the impacts on quality-of-life outcomes and use of healthcare services in people aged 5 - 25 years diagnosed with Inflammatory Bowel Disease (IBD) and the impacts of mental health conditions in those diagnosed with IBD.

Key Dates

Start date
Jan 5, 2022
Status verified
May 2025
Primary completion
Mar 31, 2023
Completion
Aug 15, 2023

Study Design

Enrollment
19,469 participants (actual)

Arms

  • Arm: IBD Cases
    All incident cases of Inflammatory Bowel Disease (IBD); comprising of Ulcerative Colitis, Crohn's Disease and IBD Unclassified in children, adolescents and young adults up to their 25th birthday. Cases will be defined based on an algorithm using diagnostic codes from the electronic medical record (EMR).
  • Arm: Matched Controls
    People without a diagnosis in their electronic medical record (ERM) of Inflammatory Bowel Disease, matched on age group, sex, ethnicity (consistent with UK census categories: White, Asian, Black, Mixed, Other), index of multiple deprivation based on postcode, and by practice where numbers allow.
  • Arm: IBD cases with mental health condition
    A subset of the IBD cases comprising of those participants with the presence of a mental health condition at the same date as their IBD diagnosis. Mental health defined by the diagnosis of any of depression (recurrent depressive disorder or depressive episode), non-phobia-related anxiety disorder (AD), eating disorders, body image disorder, attention-deficit disorder, behavioural disorders, adjustment disorder, acute stress disorder, schizophrenia, bipolar disorder or post-traumatic stress disorder
  • Arm: IBD cases without mental health condition
    A subset of the IBD cases comprising of those participants with the absence of a mental health condition at the same date as their IBD diagnosis. Mental health defined by the diagnosis of any of depression (recurrent depressive disorder or depressive episode), non-phobia-related anxiety disorder (AD), eating disorders, body image disorder, attention-deficit disorder, behavioural disorders, adjustment disorder, acute stress disorder, schizophrenia, bipolar disorder or post-traumatic stress disorder

Primary Outcome Measure

Stream 1: Percentage of Participants Who Developed Any Mental Health Condition [ Time Frame: 5 years ]

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