Changes in Cognition and Psychiatric Disorder Symptoms During Cannabis Abstinence Using a Novel Discordant Twin Design

Part of paid clinical trials in Aurora, Colorado.

Sponsor
University of Colorado, Denver
Study ID
NCT05160688
Status
Enrolling By Invitation

Conditions

  • Cannabis

Eligibility Criteria

Sex
ALL
Age
31 Years - 47 Years
Healthy Volunteers
Accepted

Interventions

  • Contingency management — BEHAVIORAL
    Participants will be paid to abstain from cannabis use.

Study Details

This study will test whether 42 days of cannabis abstinence, compared to continued cannabis use, is associated with improvements in cognition and psychiatric disorder symptoms. Identical twins, who are concordant on cannabis use, will be experimentally-manipulated to be discordant for 42 days. Each twin, within a twin pair, will be randomly assigned to either the contingency management condition, incentive-based protocol to promote cannabis abstinence, or control condition, no changes in cannabis use requested.

Key Dates

Start date
May 5, 2023
Status verified
Feb 2026
Primary completion
Apr 1, 2026
Completion
Apr 1, 2026

Study Design

Enrollment
100 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Contingency management
    Contingency management (CM) is an incentive-based intervention providing patients with tangible rewards as reinforcement for positive behaviors like abstinence from drug use. Incentives are provided with each urine sample that is drug-free and are increased with each subsequent drug-free urine sample. Participants in the CM condition will receive increasing payments for abstinence: $30 on day 3, $45 on day 5, $60 on day 7, $75 on day 14, $90 on day 21, $105 on day 28, and $120 on day 42. Participants in both conditions also receive increasing payment for visit attendance: $10 on day 1, $15 on day 3, $20 on day 5, $25 on day 7, $30 on day 14, $35 on day 21, $45 on day 28, and $55 on day 42. At the end of the baseline visit, participants in the CM condition will sign a behavioral contract with study staff that clearly outlines expectations as well as the payment schedule.
  • No Intervention: No intervention
    Participants in this condition will be monitored and will not receive any compensation for cannabis abstinence.

Primary Outcome Measure

Change in attention performance [ Time Frame: Change from baseline to day 42 ]

Locations (1)

FacilityCityStateZIPSite coordinators
Jessica M RossAuroraColorado80045-

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By research site
Jessica M Ross· Aurora, CO

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