Connectomic Deep Brain Stimulation for Obsessive Compulsive Disorder

Part of paid clinical trials in New York, New York.

Sponsor
Icahn School of Medicine at Mount Sinai
Study ID
NCT05160129
Status
Recruiting
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Conditions

  • Obsessive Compulsive Disorder (OCD)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Selective focal stimulation of ALIC-pathways — DEVICE
    DBS will be applied selectively to different electrode contacts/ segments to evaluate clinical, behavioral, and electrocortical responses of specific pathways within the ALIC.

Study Details

Deep brain stimulation (DBS) is an effective treatment for people suffering from severe obsessive-compulsive disorder (OCD) whose symptoms have failed to improve after years and multiple methods of intervention. An effective DBS target for OCD is the anterior limb of the internal capsule (ALIC) brain region. On average 60% of all OCD patients have a clinically significant response to ALIC DBS. However, ALIC DBS may become even more effective with the ability to predict which specific ALIC connections in the brain need to be stimulated for each individual OCD patient. This study therefore investigates personalized stimulation to the ALIC that allows for precise modulation of brain circuits associated with individual OCD symptoms. The study aims to specify the ideal anatomical target for ALIC DBS for maximum therapeutic benefit in each patient.

Key Dates

Start date
Aug 13, 2021
Status verified
Jun 2025
Primary completion
Mar 31, 2026
Completion
Mar 31, 2026

Study Design

Enrollment
20 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Circuit-selective DBS
    People suffering from severe obsessive-compulsive disorder (OCD)

Primary Outcome Measure

Change in Yale Brown Obsessive Compulsive Scale (Y-BOCS) [ Time Frame: Pre-surgical baseline, monthly up to 12 months postoperative ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Mount Sinai WestNew YorkNew York10019
Martijn Figee
[email protected]
212-523-8962
Martijn Figee (PRINCIPAL_INVESTIGATOR)

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By research site
Mount Sinai West· New York, NY

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