Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk

Part of paid clinical trials in Glen Oaks, New York.

Sponsor
Northwell Health
Study ID
NCT05131035
Status
Recruiting
Apply to this trial

Conditions

  • Prodromal Schizophrenia
  • Prodromal Symptoms
  • Psychosis

Eligibility Criteria

Sex
ALL
Age
14 Years - 20 Years
Healthy Volunteers
Not accepted

Interventions

  • SCORES (Specific COgnitive Remediation with Support) — BEHAVIORAL
    This study evaluates the effectiveness of a 10-week cognitive remediation program plus group coaching and therapy to improve processing speed and, in turn, social functioning and attenuated positive symptoms in CHR subjects. The SCORES (Specific COgnitive Remediation with Support) intervention is a novel CR program combined with group coaching, performance-based rewards, game-like tasks, and therapy elements to increase engagement and retention. In the 2 year, R61 phase, all participants will complete 40 hours of CR (4 hrs per week) with a mid-point assessment (20 hours of CR at 5 weeks) to determine the impact of CR on processing speed as measured by the MCCB. The second phase of the study (R33) will compare the 40 hours of speeded brain training to 40 hours of non-speeded brain training. This three year study will allow for a replication and assessment of specificity of the targeted intervention.

Study Details

This 10 week intervention, Specific Cognitive Remediation with Surround (or SCORES), is designed to target processing speed, a cognitive domain related directly to social functioning, which in turn, represents a vulnerability factor for psychosis. This remotely-delivered intervention combining targeted cognitive training exercises and group support was developed to directly impact processing speed, and at the same time, boost motivation and engagement in adolescents at risk for schizophrenia and other psychotic disorders.

Key Dates

Start date
Oct 28, 2021
Status verified
Nov 2025
Primary completion
May 31, 2026
Completion
May 31, 2026

Study Design

Enrollment
54 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Experimental: Speeded Cognitive Training
    Participants in this condition will complete 40 hours of Cognitive Remediation with a mid-point assessment (20 hours/5 weeks) to determine the impact of speeded cognitive training tasks on cognition and social function.
  • Active Comparator: Non-Speeded Cognitive Training
    Participants in this condition will complete 40 hours of Cognitive Remediation with a mid-point assessment (20 hours/5 weeks) to determine the impact of non-speeded cognitive training tasks on cognition and social function.

Primary Outcome Measure

Processing Speed domain score from the MATRICS Consensus Cognitive Battery (MCCB) [ Time Frame: Baseline, Mid-Treatment (5 weeks), Post Treatment (10 weeks) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Northwell Health- The Zucker Hillside HospitalGlen OaksNew York11042
Andrea M Auther, Ph.D.
[email protected]
718-470-8147
Danielle McLaughlin, M.A.
[email protected]
718-470-8375
Barbara A Cornblatt, Ph.D. (PRINCIPAL_INVESTIGATOR)
Ricardo E Carrion, Ph.D. (PRINCIPAL_INVESTIGATOR)

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By research site
Northwell Health- The Zucker Hillside Hospital· Glen Oaks, NY

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