Post-Concussion Musculoskeletal Injury Risks

Part of paid clinical trials in Athens, Georgia.

Sponsor
Walter Reed National Military Medical Center
Study ID
NCT05122728
Status
Recruiting
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Conditions

  • Musculoskeletal Injury

Eligibility Criteria

Sex
ALL
Age
18 Years - 40 Years
Healthy Volunteers
Accepted

Interventions

  • Post-Concussion Neuromuscular Function and Musculoskeletal Injury Risk Assessment — OTHER
    Participants will complete a comprehensive biomechanical and neuromuscular assessments to elucidate the underlying neuromuscular control mechanisms that may contribute to increased MSKI risk following concussion. Participants will also complete a battery of self-report psychosocial measures. Biomechanical Dynamic Movement Assessments: * Jump-Landing * Single Leg Hop * Anticipated Cut * Gait - Single Task * Gait - Dual Task Strength and Voluntary Muscle Activation Assessments: * Interpolated Twitch Technique * Muscular Ramp Contraction Sensory assessments: * Proprioception - Closed Chain * Passive Joint Repositioning * Light Touch Sensation Patient Reported Outcomes: * Self-Reported Musculoskeletal Injuries * National Institutes of Health Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function * PROMIS Pain Interference * PROMIS Depression * PROMIS Anxiety * Brief Resilience Scale (BRS) * Tampa Scale of Kinesiophobia (TSK-11)

Study Details

Musculoskeletal injuries (MSKI) and traumatic brain injury (TBI) are the signature injuries of the ongoing military conflicts. MSKI affect 800,000 Service Members annually and TBI have impacted more than 350,000 in the past 19 years and account for 22% of all combat casualties. Concussion, a mild form of TBI, increases MSKI risk in physically active individuals, including Service Members. The overall goal of the study is to identify the neuromuscular control mechanisms that increase MSKI risk following concussion. It is hypothesized that concussed individuals will display abnormal neuromuscular function that increases MSKI risk, as compared to non-concussed controls. The study will employ a multi-center, prospective, case-matched control observational study to identify the differences in neuromuscular function following concussion that may contribute to increased MSKI risk. Once the neuromuscular control mechanisms that increase MSKI risk following concussion are identified, targeted risk mitigation strategies can be developed to reduce MSKI risk.

Key Dates

Start date
Oct 20, 2022
Status verified
Jan 2026
Primary completion
Sep 30, 2026
Completion
Sep 30, 2027

Study Design

Enrollment
148 participants (estimated)

Arms

  • Arm: Concussed Cohort
    Active duty Service Members and physically active civilians who have self-reported as asymptomatic post-concussion.
  • Arm: Non-Concussed Cohort
    Gender, age, occupation, and physical activity matched active duty Service Members and physically active civilians who have not sustained a concussion.

Primary Outcome Measure

Changes in Jump-Landing Kinematic and Kinetic Measures [ Time Frame: Initial testing after reporting asymptomatic post-concussion, 6-Weeks post-initial testing, and 12-Weeks post-initial testing. ]

Central Contacts

Locations (3)

FacilityCityStateZIPSite coordinators
University of GeorgiaAthensGeorgia30602
Robert C Lynall, PhD
Walter Reed National Military Medical CenterBethesdaMaryland20814
Bradford D Hendershot, PhD
Womack Army Medical CenterFort BraggNorth Carolina28310-

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By research site
University of Georgia· Athens, GAWalter Reed National Military Medical Center· Bethesda, MDWomack Army Medical Center· Fort Bragg, NC

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