Muscle Blood Flow Regulation in HFpEF

Conditions

• HFpEF

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Accepted

Interventions

• Exercise training — OTHER
  Patients with HFpEF will undergo 8 weeks of exercise training.

Study Details

Heart failure with preserved ejection (HFpEF) disproportionately affects Veterans and is the number one reason for hospital discharge in the VA Health Care System. Exercise intolerance is a common complication experienced by patients with HFpEF, perpetuating physical inactivity and accelerating disease progression. This research proposal aims to elucidate mechanisms responsible for inadequate skeletal muscle blood flow and exercise intolerance in patients with HFpEF compared with healthy controls as well as following 8 weeks of exercise training in patients with HFpEF only.

Key Dates

Start date

Jul 1, 2022

Status verified

Apr 2026

Primary completion

Jul 31, 2027

Completion

Feb 29, 2028

Study Design

Enrollment

35 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Exercise training
  Patients with HFpEF will participate in the 8 weeks of supervised, two-legged, knee extensor exercise training for 3 days per week. Each exercise session will involve a 5-min warm-up and a 5-min cool-down, and exercise intensity will range between 40%-90% of maximal work rate. Maximal work rate will be re-assessed every two weeks.

Primary Outcome Measure

Six-minute walk test [ Time Frame: Change from baseline six-minute walk test distance at 8 weeks ]

Central Contacts

• Kanokwan Bunsawat, PhD
  (801) 582-1565
  [email protected]
• David W Wray, PhD
  (801) 582-1565
  [email protected]

Locations (1)

Find similar trials in Salt Lake City, UT

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