MagnetisMM-4: Umbrella Study of Elranatamab (PF-06863135) in Combination With Anti-Cancer Treatments in Multiple Myeloma

Part of paid clinical trials in Gilbert, Arizona.

Sponsor
Pfizer
Study ID
NCT05090566
Phase
PHASE2
Status
Terminated

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

The purpose of this study is to determine the Recommended Phase 2 Dose and clinical benefit of elranatamab in combination with other anti-cancer therapies in participants with multiple myeloma.

Key Dates

Start date
Oct 27, 2021
Status verified
Apr 2026
Primary completion
Feb 13, 2025
Completion
Mar 11, 2026

Study Design

Enrollment
46 participants (actual)
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Sub-Study A
    BCMA-CD3 bispecific antibody + gamma secretase inhibitor
  • Experimental: Sub-Study B
    BCMA-CD3 bispecific antibody + immunomodulatory drug

Primary Outcome Measure

SSA: Number of Participants With Dose Limiting Toxicities (DLTs)- Phase 1b Dose Escalation [ Time Frame: From Cycle 0 Day 1 through Cycle 1 Day 28 (approximately up to 35 days) ]

Locations (22)

FacilityCityStateZIPSite coordinators
Banner Gateway Medical CenterGilbertArizona85234-
Banner Gateway Medical PavilionGilbertArizona85234-
Banner MD Anderson Cancer CenterGilbertArizona85234-
Banner Health d.b.a. Banner MD Anderson Cancer CenterPhoenixArizona85012-
Beverly Hills Cancer CenterBeverly HillsCalifornia90211-
Clinical Research AdvisorsEncinoCalifornia91316-
Cedars Sinai Medical CenterLos AngelesCalifornia90048-
Cedars Sinai Medical Center Oncology IDS Pharmacy Attn:Suwicha Limvorasak ,PharmaDLos AngelesCalifornia90048-
Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute (SOCCI)Los AngelesCalifornia90048-
Clinical Research AdvisorsLos AngelesCalifornia90020-
Clinical Research AdvisorsLos AngelesCalifornia90048-
Cedars-Sinai TarzanaTarzanaCalifornia91356-
Sylvester Comprehensive Cancer Center - The Lennar Foundation Medical CenterCoral GablesFlorida33146-
University of MiamiCoral GablesFlorida33146-
Sylvester Comprehensive Cancer Center- Deerfield BeachDeerfield BeachFlorida33442-
Sylvester Comprehensive Cancer CenterMiamiFlorida33136-
UHealth TowerMiamiFlorida33136-
OIDS, The Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsBaltimoreMaryland21231-
The Johns Hopkins University School of MedicineBaltimoreMaryland21205-
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (Also Imaging Facility)BaltimoreMaryland21231-
Beth Israel Deaconess Medical CenterBostonMassachusetts02215-
Massachusetts General HospitalBostonMassachusetts02114-

Related coverage on Hipa.ai

Find similar trials in Gilbert, AZ

By condition
Multiple myeloma
By specialty
OncologyBlood cancer
By research site
Banner Gateway Medical Center· Gilbert, AZBanner Gateway Medical Pavilion· Gilbert, AZBanner MD Anderson Cancer Center· Gilbert, AZBanner Health d.b.a. Banner MD Anderson Cancer Center· Phoenix, AZBeverly Hills Cancer Center· Beverly Hills, CAClinical Research Advisors· Encino, CA

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