Neural Basis of Sensory Learning: Brain Regions

Part of paid clinical trials in Bloomington, Indiana.

Sponsor
Indiana University
Study ID
NCT05079516
Status
Recruiting
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Conditions

  • Basic Science

Eligibility Criteria

Sex
ALL
Age
18 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • Theta burst transcranial magnetic stimulation — OTHER
    Real or sham continuous theta burst TMS (cTBS) will be delivered to a location on the head, determined by randomized group assignment. cTBS consists of 600 low-intensity TMS pulses delivered over 40 seconds in a pattern of 50 Hz triplets delivered at 5 Hz.

Study Details

The purpose of this study is to understand how the sensory and motor areas of the brain work together to keep a person's hand movements accurate (sensorimotor learning). The investigators hope this information may be useful one day to improve rehabilitation techniques in patients with brain lesions.

Key Dates

Start date
Oct 26, 2021
Status verified
Apr 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
300 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Primary motor cortex--Exp 1
    Theta burst transcranial magnetic stimulation (cTBS) will be applied over primary motor cortex.
  • Experimental: Somatosensory cortex--Exp 1
    Theta burst transcranial magnetic stimulation (cTBS) will be applied over primary somatosensory cortex.
  • Sham Comparator: Vertex sham--Exp 1
    Sham theta burst transcranial magnetic stimulation (cTBS) will be applied over the vertex.
  • Experimental: Anterior superior parietal lobule--Exp 2
    Theta burst transcranial magnetic stimulation (cTBS) will be applied over Anterior superior parietal lobule.
  • Experimental: Ventral premotor cortex--Exp 2
    Theta burst transcranial magnetic stimulation (cTBS) will be applied over Ventral premotor cortex.
  • Experimental: Cerebellar cortex--Exp 2
    Theta burst transcranial magnetic stimulation (cTBS) will be applied over cerebellar cortex.
  • Sham Comparator: Vertex sham--Exp 2
    Sham theta burst transcranial magnetic stimulation (cTBS) will be applied over the vertex.

Primary Outcome Measure

Realignment [ Time Frame: 1 day ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Indiana University BloomingtonBloomingtonIndiana47405
Study Coordinator
[email protected]
8128554079

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Indiana University Bloomington· Bloomington, IN

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