Understanding Motivation in Parkinson's Patients Through Neurophysiology

Part of paid clinical trials in San Francisco, California.

Sponsor
University of California, San Francisco
Study ID
NCT05065151
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Stimulation on — OTHER
    Stimulation from Percept DBS will be on while the patient is playing a decision-making game on a computer-based application.
  • Stimulation off — OTHER
    Stimulation from Percept DBS will be off while the patient is playing a decision-making game on a computer-based application.
  • Decision Making Task — BEHAVIORAL
    Patients will be playing a decision making task through a computer-based application.

Study Details

The study aims to better understand motivation and value-based decision-making in Parkinson's patients through neurophysiology using Medtronic's Percept DBS device. By combining behavioral tasks with neural recordings, the study seeks to uncover how DBS affects motivation, particularly in relation to effort, reward, and timing.

Key Dates

Start date
Oct 30, 2021
Status verified
Jun 2026
Primary completion
Dec 1, 2030
Completion
Dec 1, 2030

Study Design

Enrollment
70 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Stimulation
    Patients will be getting standard clinically acceptable stimulation within already safety validated stimulation ranges through their Medtronic Percept device.
  • Experimental: No Stimulation
    Patients will have stimulation turned off through their Medtronic Percept device.

Primary Outcome Measure

Percent of Risky Decisions made with Percept DBS stimulation on for Parkinson's Disease Patients [ Time Frame: The values will be collected starting from admission in clinic and the at-home paradigm. Data collection and analysis of said values can take up to three years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of California San FranciscoSan FranciscoCalifornia94158
Sarah Wang, PhD
[email protected]
415-353-7885
Simon J Little, MBBS, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in San Francisco, CA

By condition
Parkinson's disease
By specialty
NeurologyBrain disorders
By research site
University of California San Francisco· San Francisco, CA

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