A Study to Measure the Effect of Brain Stimulation on Hand Strength and Function in Patients With Brain Tumors

Part of paid clinical trials in Milwaukee, Wisconsin.

Sponsor: Medical College of Wisconsin
Study ID: NCT05023434
Status: Recruiting

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Conditions

Brain Cancer
Brain Tumor
Motor Cortex; Lesion

Eligibility Criteria

Sex: ALL
Age: 18 Years - 75 Years
Healthy Volunteers: Accepted

Interventions

Intraoperative Brain Simulation - Alternate Stimulation Parameters — PROCEDURE
Additional stimulation parameters outside of standard of care during intraoperative brain stimulation to aid in motor mapping.

Study Details

The neurosurgical standard of care for treating a patient with a tumor invading hand primary motor cortex (M1) includes performing a craniotomy with intraoperative direct electrical stimulation (DES) mapping and to resect as much tumor as possible without a resultant permanent neurological deficit. However, the subjective nature of current intraoperative hand motor assessments do not offer a comprehensive understanding of how hand strength and function may be impacted by resection. Additionally, there is a paucity of data to inform how altering DES parameters may effect motor mapping. Here, the investigators seek to demonstrate a feasible, standardized protocol to quantitatively assess hand strength and function and systematically assess several stimulation parameters to improve intraoperative measurements and better understand how cortical stimulation interacts with underlying neural function.