Neurocognitive Outcomes After Whole Brain Radiation Therapy for Hematologic Malignancies

Part of paid clinical trials in Houston, Texas.

Sponsor
M.D. Anderson Cancer Center
Study ID
NCT05011045
Status
Recruiting
Apply to this trial

Conditions

  • Central Nervous System Lymphoma
  • Hematopoietic and Lymphoid Cell Neoplasm
  • Leukemia
  • Lymphoma
  • Plasma Cell Myeloma
  • Secondary Central Nervous System Lymphoma

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Magnetic Resonance Imaging — PROCEDURE
    Undergo MRI
  • Neurocognitive Assessment — OTHER
    Undergo neurocognitive function assessment
  • Quality-of-Life Assessment — OTHER
    Complete questionnaires
  • Questionnaire Administration — OTHER
    Complete questionnaires

Study Details

This study assesses neurocognitive outcomes after receiving radiation therapy to the brain (whole brain radiation therapy) in patients with blood cancers (hematologic malignancies). This may help researchers learn more about the effects of whole brain radiation therapy on memory and thinking in patients with blood cancer.

Key Dates

Start date
Jan 9, 2020
Status verified
May 2026
Primary completion
Oct 31, 2026
Completion
Oct 31, 2026

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Observational (neurocognitive assessment, questionnaires, MRI)
    Patients undergo neurocognitive function assessments, complete questionnaires over 8-10 minutes and undergo standard of care MRI at baseline (within 4 weeks before the first day of WBRT), 2, 6, 12 months after RT completion, then annually for 5 years.

Primary Outcome Measure

Cognitive outcomes [ Time Frame: Up to 5 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
M D Anderson Cancer CenterHoustonTexas77030
Dustin M. Silk
[email protected]
713-563-3090
Bouthaina S. Dabaja (PRINCIPAL_INVESTIGATOR)

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