Brain Mechanisms Supporting Cannabis-induced Pain Relief

Part of paid clinical trials in La Jolla, California.

Sponsor
University of California, San Diego
Study ID
NCT04982965
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Back Pain
  • Chronic Low Back and Leg Pain
  • Chronic Low-back Pain (cLBP)
  • Degenerative Disc Disease
  • Lower Back Pain
  • Lumbar Radiculopathy
  • Sciatica

Eligibility Criteria

Sex
ALL
Age
21 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • Active Cannabis — DRUG
    400 mg of vaporized and inhaled active cannabis (5.1%)
  • Placebo Cannabis — DRUG
    400 mg of vaporized and inhaled placebo cannabis (\<.1%)

Study Details

Chronic low back pain is a common and disabling condition that affects millions of people in the United States. Many people with chronic low back pain do not get enough relief from current treatments. Cannabis may help reduce pain, but researchers do not fully understand how it affects the brain in people with chronic pain. The purpose of this study is to examine how inhaled cannabis changes brain activity and reduces pain in people with chronic low back pain. Results from this study may help researchers better understand how cannabis works for pain and support the development of improved pain treatments.

Key Dates

Start date
May 7, 2021
Status verified
Jan 2026
Primary completion
Jan 15, 2027
Completion
Mar 15, 2027

Study Design

Enrollment
100 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Active THC
    Participants will be administered 400mg of vaporized cannabis (5.1%) before pain testing and fMRI.
  • Placebo Comparator: Placebo THC
    Participants will be administered 400mg of vaporized cannabis (\<.1%) before pain testing and fMRI.

Primary Outcome Measure

Cerebral Blood Flow (CBF) [ Time Frame: All data will be collected at the single study session (Day 1). ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Center for Functional MRI - W.M.Keck BuildingLa JollaCalifornia92093
Madelynn Meredith, BS
[email protected]
619-431-1850
Yasmeen Esshaki, MA
[email protected]
619-786-0375
Fadel Zeidan, PhD (PRINCIPAL_INVESTIGATOR)

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Center for Functional MRI - W.M.Keck Building· La Jolla, CA

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