Effect of Magnesium Sulfate Bolus on Intraoperative Neuromonitoring

Conditions

• Intraoperative Neurophysiological Monitoring
• Magnesium Sulfate

Eligibility Criteria

Sex

ALL

Age

18 Years - 80 Years

Healthy Volunteers

Not accepted

Interventions

• Magnesium sulfate — DRUG
  Effect of 40mg/kg Magnesium sulfate bolus dosed to ideal body weight on intraoperative neuromonitoring
• Normal Saline — DRUG
  20 ml of normal saline bolus will be administered to the control group over 10 mins.

Study Details

Magnesium Sulfate(MgSo4) is increasingly being used as part of the multimodal pain regimen in the perioperative period. The intraoperative neurophysiological monitoring (IONM) is utilized in complex spine and cranial surgeries to assess the functional integrity of the neural pathways. The effect of Magnesium sulfate on IONM has not been studied. This is a prospective, double blind, randomized placebo controlled trial to study the effect of Magnesium sulfate bolus on the amplitude and latency of somatosensory(SSEPs) and motor evoked potentials(MEPs) in patients undergoing surgery requiring IONM.

Key Dates

Start date

Mar 18, 2022

Status verified

Apr 2026

Primary completion

Mar 31, 2027

Completion

Mar 31, 2027

Study Design

Enrollment

50 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Arms

• Experimental: Magnesium sulfate arm
  MgSo4 diluted to 20% will be administered at 40 mg/kg dosed to ideal body weight over 10min to the study arm followed by 10mg/kg/hr infusion.
• Placebo Comparator: Normal Saline
  20 ml of normal saline bolus will be administered to the control group over 10 mins.

Primary Outcome Measure

Change in the amplitude of SSEPs. [ Time Frame: Up to 30 minutes after the end of bolus dose of MgSO4 or Normal saline. ]

Central Contacts

• Rashmi Vandse, MD
  9095584000
  [email protected]

Locations (1)

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