Ketamine Infusion for Neuropathic Pain in Brachial Plexus Injuries

Part of paid clinical trials in Rochester, Minnesota.

Sponsor
Mayo Clinic
Study ID
NCT04933149
Phase
PHASE4
Status
Enrolling By Invitation

Conditions

  • Brachial Plexus Injury

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Ketamine Infustion — DRUG
    Intravenous infusion at 0.5 mg/kg/hr from induction to emergence from anesthesia during the subject's brachial plexus reconstruction surgery. In addition, subjects will receive postoperative ketamine infusion of 0.1-0.3 mg/kg/hr for 24 hours titrated to side effects while patients are admitted to the hospital following surgery.

Study Details

The purpose of this study is to assess pre- and postoperative neuropathic pain in patients with traumatic brachial plexus injuries to determine if intraoperative ketamine infusion affect neuropathic pain associated with avulsion injuries of the brachial plexus.

Key Dates

Start date
Dec 15, 2021
Status verified
Apr 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
100 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Ketamine Infusion Group
    Subjects will receive ketamine infusion during their planned surgery and postoperatively.
  • No Intervention: Standard of Care Group
    Subjects will receive general anesthesia as standard of care during their planned surgery

Primary Outcome Measure

Change in PROMIS Pain Quality - Neuropathic Pain (PQ-Neuro) score [ Time Frame: Baseline, 1 week ]

Locations (1)

FacilityCityStateZIPSite coordinators
Mayo Clinic in RochesterRochesterMinnesota55905-

Find similar trials in Rochester, MN

By research site
Mayo Clinic in Rochester· Rochester, MN

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