Technical Development of Cardiovascular Magnetic Resonance Imaging

Part of paid clinical trials in Washington D.C., District of Columbia.

Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Study ID
NCT04927429
Status
Recruiting
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Conditions

  • Cardiovascular Disease

Eligibility Criteria

Sex
ALL
Age
18 Years - 100 Years
Healthy Volunteers
Accepted

Study Details

Background: In the U.S., over 6.5 million people have heart failure. Researchers want to develop new testing methods for cardiovascular problems using magnetic resonance imaging (MRI) to improve the clinical diagnosis and management of people with heart failure. Objective: To develop and test new methods for imaging the heart and blood vessels using MRI. Eligibility: People ages 18 years and older who are having an MRI of their heart or blood vessels. Healthy volunteers are also needed. Design: Participants will be screened with a medical history. Participants will have a physical exam and blood tests. They will have an electrocardiogram (ECG) to measure the heart s electrical activity. Then they will have their scheduled MRI scan. The MRI scanner is a large, hollow tube. Participants will lie on a table that moves in and out of the tube. During the MRI, they may have contrast dye injected through an intravenous line inserted into their arm or hand. ECG may be used to monitor their heartbeat or coordinate pictures with their heartbeat. A flexible belt may be used to monitor their breathing. A finger probe may be used to track their heart rate and/or oxygenation level. Their blood pressure may be measured. Pictures may be taken of their blood vessels, heart, and lungs before, during, and after they get medicine to increase blood flow. They may lie flat and pedal a stress bicycle to increase their heart rate. Participation will last for 5 years. During that time, participants may receive a yearly survey about their health. They may be contacted for an optional follow-up MRI within 2 years of their MRI.

Key Dates

Start date
Apr 8, 2024
Status verified
Apr 2026
Primary completion
Aug 31, 2026
Completion
Dec 31, 2031

Study Design

Enrollment
3,400 participants (estimated)

Arms

  • Arm: Affected participants
    Participants with a clinically indicated referral for cardiac MRI
  • Arm: Healthy participants
    Healthy individuals of various ethnicities to serve as reference ranges

Primary Outcome Measure

To evaluate performance of novel pulse sequences for cardiovascular MRI in patients and healthy volunteers of both genders [ Time Frame: 1 day ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Medstar Washington Hospital CenterWashington D.C.District of Columbia20010
James H. Boscoe, MA, CIP
[email protected]
301-560-2912
National Institutes of Health Clinical CenterBethesdaMaryland20892
For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)
[email protected]
800-411-1222

Find similar trials in Washington D.C., DC

By research site
Medstar Washington Hospital Center· Washington D.C., DCNational Institutes of Health Clinical Center· Bethesda, MD

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