Effects of White Button Mushroom on Inflammation in Obese Postmenopausal Women at High Risk of Breast Cancer

Part of paid clinical trials in Duarte, California.

Sponsor
City of Hope Medical Center
Study ID
NCT04913064
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
FEMALE
Age
21 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Questionnaire Administration — OTHER
    Ancillary studies
  • White Button Mushroom Extract — DRUG
    Given PO

Study Details

This clinical trial studies the effects of dietary white button mushroom on inflammation (the body's process of fighting against harmful things) and immune cells (white blood cells) in postmenopausal women with both high body mass index or BMI (percentage of body fat) and high risk of breast cancer. The body is in a constant state of alert when inflammation lingers at a low level and becomes chronic, as with having button mushroom is a dietary supplement that may improving responses of immune cells (white blood cells) and decreasing chronic inflammation. Information gathered from this study may help researchers determine whether white button mushroom have any effects on body fat and breast cancer risk.

Key Dates

Start date
Jul 27, 2021
Status verified
Dec 2025
Primary completion
Jan 12, 2027
Completion
Jan 12, 2027

Study Design

Enrollment
26 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION

Arms

  • Experimental: Prevention (white button mushroom)
    Participants receive white button mushroom PO daily for 3 months in the absence of disease progression or unacceptable toxicity.

Primary Outcome Measure

Relative change in levels of circulating myeloid-derived suppressor cells (MDSCs) within the peripheral blood mononuclear (PBMC) compartment [ Time Frame: Baseline up to 3 months ]

Locations (1)

FacilityCityStateZIPSite coordinators
City of Hope Medical CenterDuarteCalifornia91010
Lisa D. Yee
[email protected]
626-471-7100
Lisa D. Yee (PRINCIPAL_INVESTIGATOR)

Find similar trials in Duarte, CA

By condition
Breast cancer
By specialty
OncologyBreast oncologyWomen's health
By research site
City of Hope Medical Center· Duarte, CA

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