Spectroscopic MRI Guided Proton Therapy in Assessing Metabolic Change in Pediatric Patients With Brain Tumors

Conditions

• Malignant Brain Glioma

Eligibility Criteria

Sex

ALL

Age

N/A - 21 Years

Healthy Volunteers

Not accepted

Interventions

• Magnetic Resonance Spectroscopic Imaging — PROCEDURE
  Undergo sMRI
• Proton Therapy — DEVICE
  Target volume treatment

Study Details

This trial studies how well spectroscopic magnetic resonance imaging (MRI) guided proton therapy works in assessing metabolic change in pediatric patients with brain tumors. The non-invasive imaging, such as spectroscopic MRI may help to map the differences in tumor metabolism compared to healthy tissue without injection of any contrast agent.

Key Dates

Start date

Dec 20, 2018

Status verified

Mar 2026

Primary completion

Oct 13, 2029

Completion

Oct 13, 2030

Study Design

Enrollment

25 participants (estimated)

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Diagnostic (sMRI)
  Patients undergo sMRI over less than 1 hour within 7 days prior to start of standard of care radiation therapy and at 10 weeks.
• Active Comparator: Group 2
  Patients will undergo 3-4 sMRI scans at baseline prior to RT, 1 month, 4 months, and 7 months after RT, and/or at any time of suspected tumor recurrence.

Primary Outcome Measure

Cho/NAA ratios at baseline in tumor and in regions of tumor recurrence in patients receiving standard of care radiotherapy [ Time Frame: Through study completion, an average of 1 year ]

Central Contacts

• Bree Eaton, MD
  404-778-3473
  [email protected]

Locations (3)

Find similar trials in Atlanta, GA

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